Gastrointestinal (GI): NSAIDs that block COX-1 activity have correlations with GI troubles as a result of inhibition from the synthesis of gastroprotective agents including PGE2 together with other prostaglandins. This inhibition causes reduced mucin generation by gastric epithelial cells, less bicarbonate secretion, and less epithelial cell turnover, among other actions. https://roberty544sci3.blogsidea.com/profile