Substitution at R3 having a halogen or alkoxy group (74f–74i) led to a slight boost in cellular potency Together with the halide analogs (74g–h) displaying greatest the potency in the group. Further optimization triggered the discovery of 74i–j, with 74k as probably the most Energetic compound inside the sequence (pIC50 https://indazole-products08631.amoblog.com/the-smart-trick-of-indazole-protecting-group-that-no-one-is-discussing-53379859