There is a release of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors from the dorsal horn to lessen afferent pain transmission and produce analgesia. For that reason, medications like clonidine that focus on alpha-two receptors can affect the transmission of agony. Applies to clonidine: oral https://proleviate-nature-s-pain30637.theisblog.com/32313275/the-2-minute-rule-for-onolidine