Epidural clonidine employed as an adjunct to local anesthetics has three different mechanisms of action. First, the stimulation of alpha-two-receptors from the dorsal horn decreases ache transmission. Secondly, clonidine might cause nearby vasoconstriction that limits vascular elimination of regional epidural anesthetics. You may be able to explain to this https://hilaryv581vrm9.wikiconversation.com/user