And finally, clonidine enhances neuraxial opioids and, in combination with fentanyl, interacts within an additive way, which may reduce the dose of each component by 60% for postoperative analgesia. Clonidine treats high hypertension by stimulating α2 receptors within the brainstem, which decreases peripheral vascular resistance, reducing blood pressure level. https://michaelu050bfg7.get-blogging.com/profile